Histological evaluation of orthotopic BT142 from mice treated with JHU-083 showed solid IDH1R132H protein expression and decreased pS6(ser235/236) staining (Figure 6B), suggesting that JHU-083 reaches intracranial cells and targets mTORC1 signaling pathway in vivo

Histological evaluation of orthotopic BT142 from mice treated with JHU-083 showed solid IDH1R132H protein expression and decreased pS6(ser235/236) staining (Figure…

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