However, WT-TGT failed to drive significant Treg depletion in a low affinity F/F FcRIIIa allele donor, while, SEA-TGT treatment resulted in depletion of 25% of total Tregs, a loss of ~45% of the total TIGIT+ Tregs with this donor ( Figure?4B ); this depletion was statistically significant at the highest dose used

However, WT-TGT failed to drive significant Treg depletion in a low affinity F/F FcRIIIa allele donor, while, SEA-TGT treatment resulted…

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